Abstract
Sarcomatoid carcinoma is an uncommon variant of carcinoma. There has been no molecular-genetic study on this type of tumour as yet. Here we report the first study of chromosome allele loss in two patients with sarcomatoid liver carcinoma. Twenty-five DNA restriction fragment length polymorphism probes were used, of which sixteen revealed informative patterns in each of the patient's normal DNA. One of the patients had allelic losses shown by ten probes and a rearrangement detected by one probe in her tumour DNA. The second patient had eight allelic losses in her tumour. In summary, both tumours revealed multiple genetic changes.
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