Multipl Skleroz’un Değişik Klinik Tiplerinde ve Farkli Evrelerinde Cd4(+) Cd25(+) Regülatuar T Hücre Profili ve Foxp3 Ekspresyonu

Abstract

In the pathogenesis of MS, impairment of peripheric immune tolerance plays an important critical role in the emergence of autoimmunity. The regulatory T cells play a crucial role in the healthy function of immune tolerance. FoxP3 is a transcription factor which assignment for enough regulatory T cell expression. We compared the total percentage CD4(+) and FoxP3 expression in T lymphocytes in 31 cases including 12 RRMS, 11 SRMS and eight attack which has a definite MS regarding Mc Donald's criteria 12 healthy subjects for regulatory T cell subtypes with analysis flow cytometry in haematology laboratory. Also, we compared 7 cases in a group of 8 RRMS with an attack for before and after 1000 mg/day IVMP. The results have assesment as statistical. The regulatory cell profiles CD4(+) CD25(+), CD4(+) foxP3(+), CD4(+) CD25(+) foxP3(+),CD4(+) CD25(+) foxP3(-), and CD4(+) CD25(-) foxP3(+)of all patients were compared with the healthy control group.No significant differences existed between the groups (p>0.005). The results of regulatory cell profiles and foxP3 expression of 7 patients with attacks before treatment and after IVMP treatment were not significant (p>0.05). However, high-dose intravenous methylprednisolone therapy (IVMP) treatment was observed to cause a slight numerical increase in regulatory cell subtypes. As a consequence, we thought that the regulatory T cells play an important role in the immunopathogenesis of MS as well as its numerical sufficiency.