Abstract
Aim: N6-methyladenosine (m6A) mRNA modification plays essential roles in various cellular processes including regulation of gene expression. However, its role in Multiple Myeloma (MM) biology remains largely unknown. Therefore, the aim of this study is to investigate the expression levels of m6A-regulating enzymes in MM. Material and Methods: The expression of m6A-regulating enzymes was investigated in monoclonal gammopathy of undetermined significance (MGUS), smouldering MM (SMM), MM and in their normal counterparts using publicly available Gene Expression Omnibus datasets, GSE6477 and GSE47552.Results: By analyzing GEO DataSets GSE6477 and GSE47552, the expression levels of METTL3, METTL14 and FTO were found to be downregulated in MM, whereas no significant change was found for WTAP, ALKBH5, YTHDF1 and YTHDF2. YTHDF3 expression showed a reduction in MM based on GSE6477 data. Conclusion: The expression of m6A-modifying genes is deregulated in MM plasma cells compared to normal plasma cells. Altered expression of m6A-modifying genes seems to play a role in the promotion of MM.
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