Abstract
IntroductionNontargeted molecules of alpha-immunoconjugate (AIC) intravenously injected in clinical trials of targeted alpha therapy (TAT) could be transported by convection and diffusion along with blood or lymphatic circulation. Materials and MethodsA coupled model based on the Geant4 Monte Carlo microdosimetry technique and computational fluid dynamics was established. The transient drug delivery process and background dose to the cells along the pathway were investigated using the model. A mesoscale numerical simulation in a simple 2D capillary was performed to determine the transient toxicity of the alpha-immunoconjugate to the DNA of a targeted cell. ResultsThe simulation results indicate that the multiphysics simulation is essential to improve the accuracy of TAT simulation. ConclusionIn this work, a solution strategy for modelling AIC delivery in a blood vessel at a mesoscale level has been established. This work is the first to model different phenomena through the multiphysics simulation to investigate the whole picture of TAT.
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