Multiparametric Ultrasound Imaging of Vaginal Fibrosis Following Radiation Therapy for GYN Malignancies

Abstract

Radiation-induced vaginal fibrosis is a debilitating site-effect, affecting 80% of women post-pelvic or vaginal radiation therapy. Despite the significant incidence and severity, little research has been conducted to identify the pathophysiologic changes of vaginal toxicity. This paucity of data is largely due to the lack of an easy, reliable tool able to assess radiation-induced vaginal changes. The purpose of this study is to develop a novel multi-parametric ultrasound imaging technique to evaluate vaginal fibrosis.