Multiparametric cardiac 18F-FDG PET in humans: pilot comparison of FDG delivery rate with 82Rb myocardial blood flow

Abstract

Myocardial blood flow (MBF) and flow reserve are usually quantified in the clinic with positron emission tomography (PET) using a perfusion-specific radiotracer (e.g. 82Rb-chloride). However, the clinical accessibility of existing perfusion tracers remains limited. Meanwhile, 18F-fluorodeoxyglucose (FDG) is a commonly used radiotracer for PET metabolic imaging without similar limitations. In this paper, we explore the potential of 18F-FDG for myocardial perfusion imaging by comparing the myocardial FDG delivery rate K 1 with MBF as determined by dynamic 82Rb PET in fourteen human subjects with heart disease. Two sets of FDG K 1 were derived from one-hour dynamic FDG scans. One was the original FDG K 1 estimates and the other was the corresponding K 1 values that were linearly normalized for blood glucose levels. A generalized Renkin-Crone model was used to fit FDG K 1 with Rb MBF, which then allowed for a nonlinear extraction fraction correction for converting FDG K 1 to MBF. The linear correlation between FDG-derived MBF and Rb MBF was moderate (r = 0.79) before the glucose normalization and became much improved (r > 0.9) after glucose normalization. The extraction fraction of FDG was also similar to that of Rb-chloride in the myocardium. The results from this pilot study suggest that dynamic cardiac FDG-PET with tracer kinetic modeling has the potential to provide MBF in addition to its conventional use for metabolic imaging.