Abstract
The objectives of this study were to investigate the cardio-protective, hepatoprotective and nephroprotective effects of curcumin nanoparticle (NC) pretreatment compared to conventional curcumin (CC) on acute myocardial infarction (AMI) in rats with type 1 diabetes mellitus (T1DM). Fifty-six Wister Bratislava rats were divided into eight groups. The first four groups—C (control group), AMI (group with AMI), T1DM (group with T1DM), and T1DM-AMI (group with T1DM and AMI)—received only saline (S) during the whole experiment. Two groups—S-T1DM-CC-AMI and S-T1DM-NC-AMI—were pretreated with S before T1DM induction. The S-T1DM-CC-AMI group received CC (200 mg/Kg bw (bw—body weight)) after T1DM induction, while the S-T1DM-NC-AMI group received NC (200 mg/Kg bw) after T1DM induction. the CC-T1DM-CC-AMI group received CC (200 mg/Kg bw) during the whole experiment. Similarly, the NC-T1DM-NC-AMI group received NC (200 mg/Kg bw) over the entire experiment. T1DM was induced on day 7 using a single dose of streptozotocin (STZ). AMI was induced with isoproterenol (ISO) on day 22. Both curcumin formulations, CC and NC, prevented the following electrocardiographic changes: prolongation of the QRS complex, enlargement of QT and QTc intervals, and ST-segment elevation. Glucose levels and lipid profile parameters were reduced up to 1.9 times, while C-peptide serum levels were increased up to 1.6 times in groups that received CC or NC. Liver function parameters (aspartate transaminase, alanine transaminase) and kidney function parameters (creatinine, urea) were reduced 4.8 times, and histological changes of liver and kidney tissue were improved by CC or NC administration. Pretreatment with NC proved significantly higher cardioprotective, hepatoprotective and nephroprotective effects in the case of AMI in T1DM.
Highlights
Cardiovascular disease represents a global public health problem and the leading cause of death
The objectives of this study were to evaluate the cardio-protective, hepatoprotective and nephroprotective effects of curcumin nanoparticles (NC) pretreatment compared to conventional curcumin (CC) on experimental acute myocardial infarction (AMI) in rats with Type 1 diabetes mellitus (T1DM)
Curcumin nanoparticles offered better results in preventing elevation of these parameters when compared to conventional curcumin (Figure 7, p ≤ 0.0021), but no statistical differences were found between the two groups that received curcumin nanoparticles for neither creatinine nor for urea (Figure 7, p ≥ 0.05)
Summary
Cardiovascular disease represents a global public health problem and the leading cause of death. In 2008, the World Health Organization experts stated that cardiovascular diseases are the cause of 17.3 million deaths annually, of which 7.3 million are due to myocardial infarction, 6.2 million due to stroke, and 9.4 million through the direct involvement of hypertension [1]. Cardiovascular diseases cause four million deaths across the European continent, of which 1.9 million are in European Union countries [1]. Type 1 diabetes mellitus (T1DM) is characterized by destruction of β cells (most often autoimmune) and an absolute insulin deficiency. Type 2 diabetes mellitus (T2DM) has the highest prevalence and is characterized by insulin resistance [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
