Abstract
BackgroundThe eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction.Case presentationIn this case report, we describe a 24 year old Caucasian male who presented with severe systemic eosinophilia resulting in eosinophilic GI tract infiltration, myocarditis, pericardial and pleural effusions with dramatic improvement following drug withdrawal.ConclusionsClozapine associated eosinophilia should be suspected in the setting of eosinophilic infiltration of multiple organs.
Highlights
The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis
Clozapine-associated eosinophilia has been reported in two different forms: transient benign eosinophilia and eosinophilia with end organ damage [1,2,3]
Clozapine-associated eosinophilia with end organ damage has reportedly been associated with pancreatitis [4], pleural effusions [5], eosinophilic pneumonia [6], colitis [7], hepatitis [8], and pericarditis [9]
Summary
The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. Background Clozapine is an atypical antipsychotic medication known to have multiple hematologic side effects, most seriously agranulocytosis, and notably eosinophilia. Clozapine-associated eosinophilia has been reported in two different forms: transient benign eosinophilia and eosinophilia with end organ damage [1,2,3]. Clozapine-associated eosinophilia with end organ damage has reportedly been associated with pancreatitis [4], pleural effusions [5], eosinophilic pneumonia [6], colitis [7], hepatitis [8], and pericarditis [9].
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