Multi-Objective Optimization of Bioresorbable Magnesium Alloy Stent by Kriging Surrogate Model.

Abstract

The study proposed a multi-objective optimization method based on Kriging surrogate model and finite element analysis to mitigate the redial recoil and foreshortening ratio of bioresorbable magnesium alloy stent, and investigate the impact of strut thickness on stent expansion behavior. Finite element analysis have been carried out to compare the expansion behavior of stents with various strut thickness. Latin hypercube sampling (LHS) was adopted to generate train sample points in the design space, and the Kriging surrogate model was constructed between strut parameters and stent behavior. The genetic algorithm (GA) was employed to find the optimal solution in the global design space. Stents with thinner struts experience lower stress but suffer from severe radial recoil and foreshortening effects. The radial recoil is decreased by 66%, and foreshortening ratio is reduced by 60% for the optimized stent with U-bend width 90.7 [Formula: see text] and link width 77.9 [Formula: see text]. The errors between Kriging surrogate model and finite element simulation are 6% and 9% for the radial recoil and foreshortening ratio. Stent expansion behavior are highly dependent on design parameters, i.e. thickness, U-bend and link strut width. The purposed Multi-objective optimization approach based on Kriging surrogate model and finite element analysis is efficient in stent design optimization problem.