Abstract
Uses of a multinomial logit model for investigations of chemical interactions were investigated. The probabilities of four types of effects when mixtures of benzoylphenylureas (BPUs; diflubenzuron or trillumuron) or a juvenile hormone analogue (JHA; methoprene) with selected pyrethroids (fenvalerate or permethrin) were compared. Bioassays were done on fourth- or sixth-instar western spruce budworm, Choristoneura occidentalis Freeman). When sprayed on fourth instars, mixtures of methoprene + fenvalerate, trillumuron + fenvalerate, and dillubenzuron + permethrin produced effects significantly different from those predicted by the hypothesis of additive effectiveness. When sprayed on sixth instars, only mixtures of the BPUs with fenvalerate produced effects significantly different from this hypothesis. We conclude that the multinomiallogit model may be useful to identify interactions between chemicals that merit biochemical investigation.
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