Abstract

Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a seizure-associated rare lesion that currently appears to be a malformative lesion or hamartoma rather than a low-grade neoplastic lesion. MVNT pathognomonic magnetic resonance imaging (MRI) features allow for diagnostic accuracy in the differential diagnosis. Lesions are usually asymptomatic, nonprogressive and incidentally found requiring only imaging monitoring over time. Although uncommon, it is important to be familiar with MVNT clinical presentation and key imaging features. We here present a series of three cases with imaging findings similar to those described in the literature. These patients were followed with serial neuroimaging.

Highlights

  • Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum was first described in the neuropathology literature (Huse et al.) in 20131 in a small case series as being a purely neuronal lesion with grade I benign behavior according to the World Health Organization (WHO) classification.[1,2]

  • Intra-axial left temporoparietal lesions consisting of groupings of multiple nodules with ill-defined margins located in the juxtacortical ribbon and superficial subcortical white matter following the gyral contour with high signal intensity on T2WI and short tau inversion recovery (STIR) imaging and no DWI

  • Key imaging features are subcortical lesions in the temporal lobe consisting of multiple nodule groupings, hyperintense on T2WI

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Summary

INTRODUCTION

Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum was first described in the neuropathology literature (Huse et al.) in 20131 in a small case series as being a purely neuronal lesion with grade I benign behavior according to the World Health Organization (WHO) classification.[1,2]. An MRI study revealed subcortical lesions in the left temporal lobe consisting of multiple nodule groupings, hyperintense on FLAIR and T2, without DWI hyperintensity or gadolinium enhancement (Figure 1). MRI was performed and revealed a lesion in the parasagittal area of the right frontal lobe consisting of multiple coalescent nodules in the deep cortical ribbon, hyperintense on T2WI and FLAIR and no gadolinium enhancement (Figure 2). Intra-axial left temporoparietal lesions consisting of groupings of multiple nodules with ill-defined margins located in the juxtacortical ribbon and superficial subcortical white matter following the gyral contour with high signal intensity on T2WI and short tau inversion recovery (STIR) imaging and no DWI hyperintensity or gadolinium enhancement (Figure 3)

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