Abstract
The aim of endoscopic surveillance of Barrett's esophagus (BE) is the detection of early neoplastic lesions (ie, high-grade dysplasia or intramucosal cancer) at a stage that curative treatment, preferably by endoscopic modalities, is still possible.1–3 These early lesions, however, usually present as subtle mucosal abnormalities that are difficult to detect with standard endoscopy. It is therefore advised to obtain random biopsies such as 4-quadrant biopsy every 1–2 cm during BE surveillance; however, this practice is time consuming and associated with sampling error.
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