Abstract
We present multimodal noncontact photoacoustic (PA) and optical coherence tomography (OCT) imaging. PA signals are acquired remotely on the surface of a specimen with a Mach-Zehnder interferometer. The interferometer is realized in a fiber-optic network using a fiber laser at 1550 nm as the source. In the same fiber-optic network, a spectral-domain OCT system is implemented. The OCT system utilizes a supercontinuum light source at 1310 nm and a spectrometer with an InGaAs line array detector. Light from the fiber laser and the OCT source is multiplexed into one fiber using a wavelength-division multiplexer; the same objective is used for both imaging modalities. Reflected light is spectrally demultiplexed and guided to the respective imaging systems. We demonstrate two-dimensional and three-dimensional imaging on a tissue-mimicking sample and a chicken skin phantom. The same fiber network and same optical components are used for PA and OCT imaging, and the obtained images are intrinsically coregistered.
Highlights
Optical coherence tomography (OCT) is a high-resolution and contactless imaging method.[1,2] It allows acquisition of onedimensional, two-dimensional (2-D), and three-dimensional (3-D) depth-resolved image data ofsurface features in turbid media
As the PA signals are received at the same positions as the OCT A-scans, the PA reconstruction and the OCT image are intrinsically coregistered
This is, only the case if the correct sound velocity and refractive index are used for the PA reconstruction and the OCT image, respectively
Summary
Optical coherence tomography (OCT) is a high-resolution and contactless imaging method.[1,2] It allows acquisition of onedimensional, two-dimensional (2-D), and three-dimensional (3-D) depth-resolved image data of (sub)surface features in turbid media. OCT employs the partial coherence properties of a broadband light source and interferometry to locate the positions of reflective and backscattering interfaces. This technique was originally developed for ophthalmology, and is currently pursued worldwide intensively for further medical diagnostics of biological tissues. OCT has been used as a monitoring tool during laser surgery of laryngeal carcinoma[4] and to localize tumor margins during neurosurgery of the human cortex.[5]
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