Abstract
Multiphoton tomography based on near infrared femtosecond laser technology has become a versatile high-resolution clinical- and research-imaging tool. Here, we report on a novel moveable multimodal tomograph, the MPTcompact, based on an ultracompact chiller-free fiber-laser system. The tomograph provides in vivo optical biopsies with subcellular resolution as well as optical metabolic imaging capability based on two-photon autofluorescence, second harmonic generation, fluorescence lifetime imaging, reflectance confocal microscopy, and white light CCD imaging. Applications include cancer detection, skin research, cornea research, and in situ evaluation of anti-ageing drugs and pharmaceuticals.
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