Multimodal measurement of brain activity using fNIRS and fMRI

Abstract

Event Abstract Back to Event Multimodal measurement of brain activity using fNIRS and fMRI Uzay E. Emir1* 1 CMRR, University of Minnesota, United States Investigating principles of the human brain activity requires a multimodal approach since multimodal investigation of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal using functional near infrared spectroscopy (fNIRS) may give further insight to the underlying physiological principles and the detailed transient dynamics of the vascular response. Local paramagnetic deoxy-hemoglobin (reduced hemoglobin, HbR) is the source of BOLD signals. HbR concentration changes cause MRI signal changes by altering the local susceptibility of blood around the vessels. However, fMRI as an indirect measurement does not provide a detailed understanding of the underlying physiology, since the BOLD signal is sensitive to all spatial scales of vessels and combined effects of several physiological parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral metabolic rate of oxygen (CMRO2). fNIRS provides detailed biochemical specificity in the form of HbR and oxy-hemoglobin (HbO) concentration changes. While fNIRS offers a unique opportunity to track the concentration changes of these two molecules within a micro vascular space with high temporal resolution, it suffers from limited penetration depth and low spatial resolution. Thus, a multimodal measurement approach using fNIRS and fMRI may synergize and overcome these limitations. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008. Presentation Type: Oral Presentation Topic: Symposium 13: Potentials and Limitations of Multi-modal Neuroimaging Citation: Emir UE (2008). Multimodal measurement of brain activity using fNIRS and fMRI. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.059 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Nov 2008; Published Online: 28 Nov 2008. * Correspondence: Uzay E Emir, CMRR, University of Minnesota, Minneapolis, United States, uzay@cmrr.umn.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Uzay E Emir Google Uzay E Emir Google Scholar Uzay E Emir PubMed Uzay E Emir Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.