Abstract
The state-in-art “multimodalities” represents the incorporation of individual imaging techniques such as electron, optical and/or magnetic resonance imaging (MRI). The combination enables a comprehensive insight of the interplay within biological objects not only from the molecular level to whole organ, but also from primitive until the ulterior stages of development.The purposes of our research is to exploit the advantage in resolution limit of cathodoluminescent electron microscopy and the deep penetration emissions through biological tissue in near infrared (NIR) region in order to established a cover wide range multimodal imaging techniques from nano- to meter-scale [1]. The upconversion imaging and magnetic resonance imaging are expected to become potential constitutions of this construction.Most of imaging techniques use “energy-matter” interaction of probes and excitation sources to provide specific details about biological targets. An appropriate multimodal imaging probe is capable of interaction with varied energy source and offers detectable or enhance signals.Our aim now is to develop and investigate a multimodal probe based on rare-earth doped Gd2O3 which emits detectable signals in cathodoluminescent (CL), upconversion (UPC) imaging, as well as near infrared - near infrared (NIR-NIR) imaging. This probe is also expected to have effect on contrast of MRI. Three kinds of probes (Gd2O3 doped: Tm3+,Yb3+; Ho3+,Yb3+ and Er3+,Yb3+) were synthesized by modified homogenous precipitation method and then crystallized at 11000C. Gd2O3 nanocrystals were bombarded by electron beam and CL emissions were obtained. Upconversion and NIR emissions were confirmed by using a 980nm light source exciting the probes. Multimodal images (CL, upconverting and NIR-NIR images) of synthesized Gd2O3 nanocrystals in HeLa cells are obtained. The contrast effects of the Gd2O3 crystals in MRI at 11.7T are also determined.[1]. S. Fukushima et al., Micron 67 (2014) 90-95.
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