Abstract
A 54-year-old male diagnosed with prostate cancer was referred for 68Gallium-PSMA-11 PET/CT. The scan revealed a solitary PSMA-positive thyroid lesion. On PET/ultrasound fusion imaging, a nodule with moderate risk of malignancy (TIRADS 4B) could be unambiguously correlated. Additional 124Iodine PET/ultrasound fusion imaging revealed normal iodine uptake within the PSMA-positive thyroid nodule. Fine-needle aspiration cytology was performed using an ultrasound needle-guidance system. The cytopathological investigation confirmed a benign thyroid nodule and excluded a thyroid carcinoma as well as a prostate cancer metastasis. Immunohistochemistry was positive for thyroglobulin staining.
Highlights
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PSMA-positive thyroid uptake can be related to several diagnoses, including thyroid cancer, metastases of prostate cancer or renal cell carcinoma, benign thyroid nodules, and de Quervain’s thyroiditis [3,4,5]. 99mTc-scintigraphy did not clearly characterize the nodule (B, white arrow) and cervical 124Iodine PET/CT was performed
Fine-needle cytology was performed using an magnet-based ultrasound needle-guidance system to ensure that the cells were acquired from the PSMA-positive thyroid nodule [9]
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. For real-time PET/US fusion imaging, the PET/CT images According to anatomical landmarks on CT, e.g., spine, larynx, trachea, the PET/CT images were manually superimposed and aligned to the ultrasound images using a magnodule (15 × 13 × 8 mm) in the lower right lobe (A2, white arrows), classified as Kwak-TIRADS 4B [2].
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