Abstract
Meeting abstracts Members of the TNF SuperFamily of ligands (TNFSFs) have significant potential as immuno-oncology therapeutic agents. The TNFSFs are trimeric membrane proteins that can be cleaved into soluble single trimers. While the soluble single trimers can be easily prepared and studied, they
Highlights
Members of the TNF SuperFamily of ligands (TNFSFs) have significant potential as immuno-oncology therapeutic agents
The TNFSFs are trimeric membrane proteins that can be cleaved into soluble single trimers
For the TNFSF ligands, this requires that they be used as many-trimer multimers that mimic the natural expression of many trimers on the surface of stimulating cells
Summary
Members of the TNF SuperFamily of ligands (TNFSFs) have significant potential as immuno-oncology therapeutic agents. Multimeric forms of 4-1BBL as stimulators of T cells for adoptive immunotherapy Richard S Kornbluth1*, Victoria Snarsky1, Geoffrey W Stone2 From Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA.
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