Abstract
BackgroundA pneumococcal conjugate vaccine (PCV) has been part of the Danish childhood immunization programme since October 2007. It is administered at the ages of 3, 5 and 12 months and healthy infants younger than 90 days are consequently not vaccinated. Initially the PCV-7 vaccine was used but this was replaced by the PCV-13 in April 2010. Vaccination coverage in Denmark is approximately 90 %.The aim of this study was to present multilocus sequence typing (MLST) profiles of Streptococcus pneumoniae isolates from Danish infants (0–90 days) with invasive pneumococcal disease (IPD) in the period 2003–2013.Findings32 IPD isolates were investigated for their MLST profiles. The identified sequence types (STs) had previously been observed in other European countries. Among the clones were ST 306 (serotype 1), ST 180 (serotype 3) and ST 191 (serotype 7F).ConclusionsThe ST profile distribution in this study is similar to that observed in other European studies and show a variety of STs. Our data show that the majority of STs found in Denmark is also observed in other European countries, indicating that the IPD isolates were from clones generally circulating in Europe.
Highlights
A pneumococcal conjugate vaccine (PCV) has been part of the Danish childhood immunization programme since October 2007
Our data show that the majority of sequence type (ST) found in Denmark is observed in other European countries, indicating that the invasive pneumococcal disease (IPD) isolates were from clones generally circulating in Europe
With the introduction and use of the pneumococcal conjugate vaccines (PCV) in children, an effective protection has been provided against IPD caused by the serotypes included in the vaccines [3, 4]
Summary
A pneumococcal conjugate vaccine (PCV) has been part of the Danish childhood immunization programme since October 2007. Conclusions: The ST profile distribution in this study is similar to that observed in other European studies and show a variety of STs. Our data show that the majority of STs found in Denmark is observed in other European countries, indicating that the IPD isolates were from clones generally circulating in Europe.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
