Abstract
Multilayer microcapsules fabricated via the layer-by-layer (LbL) assembly method with tailored structures and functionalities are promising candidates as carriers of drugs, growth factors, and other bioactive agents in biomedicine. The capsules loaded with growth factors also can be integrated with scaffolds to form bioactive scaffolds for regenerative medicine. This chapter discusses first the recent progress of the fabrication of LbL microcapsules including manipulation of their properties by chemical cross-linking, microcapsules based on new driving forces, microcapsules with subcompartments, and microcapsules which can transform their shape. Their potential applications as drug delivery carriers, emphasizing on the new encapsulation methods, the surface modification of smaller particles, as well as the deformation and recovery behavior of microcapsules, are demonstrated. Finally, the loading of growth factors into multilayer capsules and their incorporation into scaffolds are introduced.
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