Abstract
Abstract[2.2]Paracyclophane (PCP) derivatives have been promising platforms to study the element of planar chirality and through‐space electronic communications in π‐stacked molecular systems. To access enantiomerically pure derivatives thereof, a kinetic resolution of 4‐acetyl[2.2]‐PCP employing a ruthenium‐catalyzed enantioselective hydrogenation process was developed. This method can be performed on a multigram‐scale and gives access to enantiomerically pure derivatives with planar and central chirality of (Rp)‐4‐acetyl‐PCP (≥97% ee, 43%) and (Sp,S)‐PCP derivatives (≥97% ee, 46%), which are useful intermediates for the synthesis of sterically demanding PCP‐based ligand/catalyst systems and chiral synthons for engineering cyclophane‐based chiroptical materials.magnified image
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