Abstract
Engineered-nanotubular structures offer exciting progress toward the design of multifunctional medical implants. Using facile electrochemical technique based on low cost electrode materials, we have been able to fabricate three-dimensional high quality self-aligned nanotubes on the surface of arbitrary geometries. We have observed that the fabrication of TiO2 nanotubes with elastic modulus close to actual bone promotes osteoblast growth. In addition TiO2 nanotubes could be considered a suitable alternative route for the development of drug-eluting antimicrobial implants due to the fact that these nanostructures are not an added coating but rather are rooted in the implants and will not delaminate from the surface. Such drug-eluting implants can prevent unnecessary side effects caused by oral administration of drugs, increase drug efficiency, and prevent infection related implant complications and failures. The PI would like to acknowledge the funding from NSF CAREER as well financial support from NSF-Major Research Instrumentation, Pacific Northwest National Laboratories, North Carolina Nonwoven Institute, Chicago Biomedical Consorsium, and USG company.
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