Abstract
AbstractRecently, multifunctional polymers for protein conjugation have been facilely synthesized through the multicomponent reactions (MCRs). In this mini‐review, current progress in the generation of multifunctional polymers with protein‐reactive groups via MCRs is summarized. These multifunctional polymers react with model therapeutic proteins, forming multifunctional polymer‐protein conjugates, which are prototypes of sophisticated theranostic agents and antibacterial vaccine candidates. In comparison with the traditional multi‐step synthesis, the preparation of multifunctional polymers for protein conjugation through MCRs is straightforward and convenient. Due to these properties, MCRs have the potential to become a new general strategy to achieve polymer‐protein conjugates for biological and medical applications.
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