Abstract
Tissue adhesives have emerged as an alternative to sutures and staples for wound closure and reconnection of injured tissues after surgery or trauma. Owing to their convenience and effectiveness, these adhesives have received growing attention particularly in minimally invasive procedures. For safe and accurate applications, tissue adhesives should be detectable via clinical imaging modalities and be highly biocompatible for intracorporeal procedures. However, few adhesives meet all these requirements. Herein, we show that biocompatible tantalum oxide/silica core/shell nanoparticles (TSNs) exhibit not only high contrast effects for real-time imaging but also strong adhesive properties. Furthermore, the biocompatible TSNs cause much less cellular toxicity and less inflammation than a clinically used, imageable tissue adhesive (that is, a mixture of cyanoacrylate and Lipiodol). Because of their multifunctional imaging and adhesive property, the TSNs are successfully applied as a hemostatic adhesive for minimally invasive procedures and as an immobilized marker for image-guided procedures.
Highlights
Tissue adhesives have emerged as an alternative to sutures and staples for wound closure and reconnection of injured tissues after surgery or trauma
Since minimally invasive procedures are typically guided by real-time imaging modalities, such as X-ray fluoroscopy, computed tomography (CT), ultrasonography, and fluorescence imaging, it is useful that the applied tissue adhesives are visible with such imaging modalities for accurate and safe applications[11,12,13]
The tantalum oxide (TaOx)/SiO2 core/shell nanoparticle (TSN) glue is clearly visualized by real-time imaging modalities, which facilitates image-guided, less-invasive procedures using this material, and exhibits adhesive property similar to that of a mixture of cyanoacrylate and Lipiodol (CA-Lp) used in clinical practice (Fig. 1b)
Summary
Tissue adhesives have emerged as an alternative to sutures and staples for wound closure and reconnection of injured tissues after surgery or trauma. Owing to their convenience and effectiveness, these adhesives have received growing attention in minimally invasive procedures. We show that biocompatible tantalum oxide/silica core/shell nanoparticles (TSNs) exhibit high contrast effects for real-time imaging and strong adhesive properties. The biocompatible TSNs cause much less cellular toxicity and less inflammation than a clinically used, imageable tissue adhesive (that is, a mixture of cyanoacrylate and Lipiodol) Because of their multifunctional imaging and adhesive property, the TSNs are successfully applied as a hemostatic adhesive for minimally invasive procedures and as an immobilized marker for image-guided procedures. We design core-shell structured tantalum oxide-silica nanoparticles as tissue adhesives in image-guided surgery
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