Multifunctional Nanocomposite with Magnetism, Thermosensitivity and Surface Enhanced Raman Scattering Effect.

Abstract

Multifunctional Fe3O4 @poly(N-isopropylacrylamide-co-acrylamide), Au (Fe3O4 @PNIPAM-AAM, Au) composite with magnetism, themosensitivity, surface enhanced Raman scattering (SERS) effect and drug delivery ability was successfully prepared. Transmittance measurements at 350 nm confirm the composite has a lower critical solution temperature (LCST) about 41 degrees C. Due to the network structure of PNIPAM-AAM, the composite is also an ideal drug carrier. An encapsulation efficiency of 90 wt% was demonstrated by using Ampicillin as a model drug. The drug release process was closely related with the environmental temperature, which was dramatically accelerated at temperature above LCST, and a much greater release amount was achieved. The Raman enhancement effect of such versatile composite was evaluated by using crystal violet (CV) as a probe molecule, which verified the composite is an effective SERS substrate.