Abstract
Evaluation of: Medarova Z, Pham W, Farrar C, Petkova V, Moore A: In vivo imaging of siRNA delivery and silencing in tumors. Nat. Med. 13(3), 372–377 (2007) [1] . A recent paper on the fabrication and biological evaluation of a multifunctional nanoparticle for image-guided siRNA delivery is evaluated here. Superparamagnetic iron-oxide nanoparticle conjugates containing a cell-penetration peptide and a near-infrared fluorescence-imaging probe have been used to deliver siRNA to tumors. The conjugates demonstrated enhanced uptake and gene silencing in vitro and in vivo. The conjugates were monitored by magnetic resonance imaging (MRI) and near-infrared fluorescence imaging techniques and provided visual evidence of tumor uptake and therapeutic efficacy. I evaluate the results of this study and discuss the challenges in the development of these multifunctional drug-delivery nanoplatforms.
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