Multifunctional mussel-inspired copolymerized epigallocatechin gallate (EGCG)/arginine coating: the potential as an ad-layer for vascular materials.

Rifang Luo,Jin Wang,Yunbing Wang,Nan Huang,Linlin Tang,Lingxia Xie

doi:10.1093/rb/rbw027

Rifang Luo, Jin Wang + Show 4 more

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https://doi.org/10.1093/rb/rbw027

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Abstract

Surface properties are considered to be important factors in addressing proper functionalities. In this paper, a multifunctional mussel-inspired coating was prepared via the direct copolymerization of epigallocatechin gallate (EGCG) and arginine. The coating formation was confirmed by X-ray photoelectron spectroscopy and Fourier transform infrared spectra. The EGCG/arginine coating contained diverse functional groups like amines, phenols and carboxyls, whose densities were also tunable. Such mussel-inspired coating could also be applied as an ad-layer for its secondary reactivity, demonstrated by quartz crystal microbalance technique. Moreover, the tunable surface density of phenols showed potential ability in modulating endothelial cell and smooth muscle cell viability. The coatings rich in phenols presented excellent free radical scavenging property. Current results strongly indicated the potential of EGCG/arginine coatings to be applied as an ad-layer for vascular materials.

Highlights

As generally accepted, cardiovascular diseases have the highest fatality rate in clinic and vascular stent has been demonstrated for its beneficial effects [1, 2]
After coating formation, they were ultrasonically cleaned with deionized water and named as epigallocatechin gallate (EGCG)/R-x/y, where R is the abbreviation of arginine, x and y represented the final concentration of EGCG
ATR-FTIR spectroscopy was used to analysis the chemical structures of the modified surfaces

Summary

Introduction

Cardiovascular diseases have the highest fatality rate in clinic and vascular stent has been demonstrated for its beneficial effects [1, 2]. During angioplasty, the acute vessel wall injury often causes the increased incidence of restenosis, thrombosis and intimal hyperplasia [3,4,5]. Surface properties are considered to be important factors in addressing proper surface functionalities. Surface modification techniques are of significance in obtaining desired surface functionality. The obtaining of proper biofunctions is still a challenge due to the insufficient reactive functional groups on the material surface. How to select a proper surface modification technique from the tool box and construct a multifunctional ad-layer is a hot topic in current research [6]

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