Abstract
Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing is desiderated with the function of promoting revascularization and anti-bacteria. Herein, a multifunctional injectable composite hydrogel was prepared by incorporation of the cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG was synthesized by combining sol-gel method with template method, which maintained spherical shape, chemical structure and phase constitution of bioactive glass (BG). The Ce-BG/GelMA hydrogels had good cytocompatibility, promoted endothelial cells migration and tube formation by releasing Si ion. In vitro antibacterial tests showed that 5 mol % CeO2-containing bioactive glass/GelMA (5/G) composite hydrogel exhibited excellent antibacterial properties. In vivo study demonstrated that the 5/G hydrogel could significantly improve wound healing in diabetic rats by accelerating the formation of granulation tissue, collagen deposition and angiogenesis. All in all, these results indicate that the 5/G hydrogel could enhance diabetic wound healing. Therefore, the development of multifunctional materials with antibacterial and angiogenic functions is of great significance to promote the repair of diabetic wound healing.
Highlights
Introduction iationsThe International Diabetes Federation estimated that the global prevalence of diabetes would be 693 million in 2045 [1]
According to the results of TEM imagines and size distributions, we found that 0 Ce-bioactive glass (BG) and 2 Ce-BG were similar in diameter and the diameter of 5 Ce-BG was smaller than 0 Ce-BG and 2 Ce-BG
We found that the incorporation of BGs into hydrogel matrix can reduced colony numbers of bacteria, but the effect is not obvious (Figure 5)
Summary
Introduction iationsThe International Diabetes Federation estimated that the global prevalence of diabetes would be 693 million in 2045 [1]. In people diagnosed with diabetes, the lifetime risk of foot ulcers is estimated to be 15% to 25% [2]. It has a high rate of disability and death, seriously affects the patients’ life quality, shortens life expectancy and brings heavy social burden. The rate of death risk within 5 years in patients with diabetic foot ulcers (DFUs) is 2.5 times that in patients without DFUs [3]. Angiogenesis plays a vital role in wound healing, because neovascularization is responsible for transporting nutrients and growth factors and removing wastes from new tissue forming sites [4]. Recent studies have shown that BG has the ability to promote angiogenesis and repair soft tissue wounds [5]
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