Year-end Sale % OFF 
Abstract
Chronic inflammation mediated by artery infiltrated macrophages plays critical role in artery restenosis after endovascular therapy. Evidence has demonstrated the potential ability of photothermal therapy (PTT) in eliminating chronic inflammation by targeting inflammatory cells including macrophages. Recently, increasing attention has been payed to copper chalcogenide nanocrystals doped of radiocontrast agent, e.g., bismuth (Bi) for computed tomography (CT) guided PTT. However, the application of imaging guided PTT in preventing artery restenosis is lacking and limited. Herein, a novel multifunctional CuBiS2 nanoparticles (CuBiS2 NPs) were synthesized for CT imaging guided PTT in artery re-stenosis prevention. The optimum amount and other conditions of CuBiS2 NPs were optimized to exert the maximum ablation effect on macrophages with good biocompatibility. In vivo carotid injury model revealed that CuBiS2 NPs exhibited promising therapeutic effect on inhibition of artery stenosis by eliminating macrophages with excellent CT imaging ability. The recent study highlights a new cost-effective metal nanostructures-based nanotechnology in prevention of artery restenosis after endovascular therapy.
Highlights
Atherosclerosis remains a devastating disease affecting cardio/cerebrovascular system with high morbidity and mortality (Toyohara et al, 2020)
EDS analysis (Supplementary Figure S1) showed that the products was composed of three elements (i.e., Cu, Bi, and S), further indicating the high purity of the CuBiS2 NPs
A carotid artery inflammation/endothelium injury model was conducted in ApoE−/− mice by mechanical injury to intima using a 29G Syringe needle mimicking endovascular treatment related endothelium injury to further validate the feasibility of CuBiS2 NPs based photothermal therapy (PTT) for inhibiting artery restenosis (Supplementary Figure S2)
Summary
Atherosclerosis remains a devastating disease affecting cardio/cerebrovascular system with high morbidity and mortality (Toyohara et al, 2020). Evidence has been growing that inflammatory macrophages play crucial role in artery restenosis after endovascular treatment (Sun et al, 2016; Pei et al, 2019). We have previously reported that other nanoparticles, e.g., CuCo2S4 nanocrystals, MoO2 nanoclusters, Fe3S4 nanoparticles, polypyrrole nanoparticles, and gold nanorods as PTT agents, can effectively alleviate inflammation by eliminating inflammatory macrophages (Peng et al, 2015; Qin et al, 2015; Wang et al, 2019; Zhang et al, 2019). Growing evidence suggest that nanoparticles as PTT agents may be an attractive and promising therapeutic target for chronic inflammation, including artery re-stenosis. Askari and Askari (2019) reported that CuBiS2 demonstrated good photothermal property and showed anticancer effect on AGS cancer cell line via apoptosis pathway in vitro. Histologic analysis of major organs and blood examination were performed to evaluate the biocompatibility of CuBiS2 NPs
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
