Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

Xiaoxuan Lu,Zichen Wu,Xiaowei Wang,Shuang Wang,Hua Qiu,Kehui Xu,Jialong Chen,Xiangyang Li

doi:10.3389/fbioe.2021.783816

Abstract

Titanium and its alloys are dominant material for orthopedic/dental implants due to their stable chemical properties and good biocompatibility. However, aseptic loosening and peri-implant infection remain problems that may lead to implant removal eventually. The ideal orthopedic implant should possess both osteogenic and antibacterial properties and do proper assistance to in situ inflammatory cells for anti-microbe and tissue repair. Recent advances in surface modification have provided various strategies to procure the harmonious relationship between implant and its microenvironment. In this review, we provide an overview of the latest strategies to endow titanium implants with bio-function and anti-infection properties. We state the methods they use to preparing these efficient surfaces and offer further insight into the interaction between these devices and the local biological environment. Finally, we discuss the unmet needs and current challenges in the development of ideal materials for bone implantation.

Highlights

With the aging of the population, the incidence of orthopedic diseases has increased, and the use of orthopedic implants has increased rapidly
The results showed that the pH 10/0.1 group had obvious osteogenesis in bacterial environment, which may be due to its strong antibacterial properties to kill the surrounding bacteria and promote mineralization to achieve good osseointegration
Aseptic loosening and infection are still challenges in fabricating coatings for orthopedic and orthodontic implants, so we introduce the current strategies combating the aseptic loosening and infection of titanium-based implants in this review

Summary

Introduction

With the aging of the population, the incidence of orthopedic diseases has increased, and the use of orthopedic implants has increased rapidly. Some researchers used MAO to prepare manganesetitanium dioxide (Mn-TiO2) microporous coatings on titanium surface, which showed good biocompatibility and osteogenic property (Zhao et al, 2020a).

Results

Conclusion