Multifocal Micronodular Pneumocyte Hyperplasia in Tuberous Sclerosis: an 8-Year CT Follow-Up

Abstract

Although the most common pulmonary manifestation of tuberous sclerosis complex (TSC) is lymphangiomyomatosis, multifocal micronodular pneumocyte hyperplasia (MMPH) can also be seen in up to half of the patients with TSC. Computed tomography is the modality of choice for diagnosis and follow-up of MMPH which is typically appear as multiple, subcentimeter, randomly distributed solid and groundglass nodules. The awareness of this entity in patients with TSC will avoid unnecessary further work-up for underlying infectious or neoplastic causes.