Abstract
There is an inherent trade-off between transverse resolution and depth of field (DOF) in optical coherence tomography (OCT) which becomes a limiting factor for certain applications. Multifocal OCT and interferometric synthetic aperture microscopy (ISAM) each provide a distinct solution to the trade-off through modification to the experiment or via post-processing, respectively. In this paper, we have solved the inverse problem of multifocal OCT and present a general algorithm for combining multiple ISAM datasets. Multifocal ISAM (MISAM) uses a regularized combination of the resampled datasets to bring advantages of both multifocal OCT and ISAM to achieve optimal transverse resolution, extended effective DOF and improved signal-to-noise ratio. We present theory, simulation and experimental results.
Highlights
Optical coherence tomography (OCT), is an optical imaging method that reveals the 3D structure of semitransparent samples with micron-resolution [1,2,3,4,5,6]
We present a method of 3-D optical imaging that combines multifocal OCT and interferometeric synthetic aperture microscopy (ISAM)
Seeing the trade-off OCT is facing and the advantages and challenges of interferometric synthetic aperture microscopy (ISAM) and multifocal OCT, we have developed a new imaging technique which combines the advantages of both multifocal OCT and ISAM
Summary
Optical coherence tomography (OCT), is an optical imaging method that reveals the 3D structure of semitransparent samples with micron-resolution [1,2,3,4,5,6]. The transverse resolution degrades as the position of reconstruction is further away from focal plane, where the scanning beam diverges in width. If the DOF is increased to 182 μm, which can be implemented using a 0.05 NA scanning beam, the best possible transverse resolution degrades to 4.55 μm, as can be seen at the upper sample point. Compared with each set of OCT data, the multifocal OCT image shows an improved resolution over the whole depth, or from another point of view, enables a larger DOF. Compared with multifocal OCT, ISAM further shifts the curve to the upper-right quadrant of the plot, mitigating the trade-off
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