Abstract
Endobronchial involvement of extrapulmonary malignant tumors is uncommon and mostly associated with breast, kidney, colon, and rectum carcinomas. A 68-year-old male with a prior diagnosis of colon non-Hodgkin lymphoma (NHL) was admitted to the hospital with a complaint of cough, sputum, and dyspnea. The chest radiograph showed right hilar enlargement and opacity at the right middle zone suggestive of a mass lesion. Computed tomography of thorax revealed a right-sided mass lesion extending to thoracic wall with the destruction of the third and the fourth ribs and a right hilar mass lesion. Fiberoptic bronchoscopy was performed in order to evaluate endobronchial involvement and showed stenosis with mucosal tumor infiltration in right upper lobe bronchus. The pathological examination of bronchoscopic biopsy specimen reported diffuse large B-cell lymphoma and the patient was accepted as the endobronchial recurrence of sigmoid colon NHL. The patient is still under treatment of R-ICE (rituximab-ifosfamide-carboplatin-etoposide) chemotherapy and partial regression of pulmonary lesions was noted after 3 courses of treatment.
Highlights
Endobronchial involvement of extrapulmonary malignant tumors is uncommon and mostly associated with breast, kidney, colon, and rectum carcinomas [1, 2]
The patient was treated with 8 courses of R-CHOP (rituximab, cyclophosphamide, Case Reports in Pulmonology biopsy specimen was reported as diffuse large B-cell lymphoma and the patient was accepted as the endobronchial recurrence of sigmoid colon non-Hodgkin lymphoma (NHL) (Figure 3)
We presented an endobronchial diffuse large B-cell lymphoma in a patient with colon diffuse large Bcell lymphoma (DLBCL) in which complete remission was achieved and no recurrence was noted during three months of followup
Summary
Endobronchial involvement of extrapulmonary malignant tumors is uncommon and mostly associated with breast, kidney, colon, and rectum carcinomas [1, 2]. The lung is a frequent site for lymphoma involvement, endobronchial metastasis of non-Hodgkin lymphoma (NHL) is extremely rare. Extranodal lymphomas originating in solid organs account for one-third of all cases of NHL. Gastrointestinal (GI) tract is the most common site of extranodal lymphomas. GI tract lymphomas occur most commonly in the stomach and colorectal NHL accounts for only 10–20% of them [3]. Mucosaassociated lymphoid tissue (MALT) and diffuse large Bcell lymphoma (DLBCL) are the most commonly observed histological subtypes in the GI tract [4]. DLBCL of the GI is an aggressive lymphoma which more commonly affects males with a median age of 50–60 years [5]. We present a patient with endobronchial involvement of diffuse large B-cell lymphoma who has completely remitted sigmoid colon NHL as a primary site
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