Abstract
Dimenhydrinate (NN-dimethyl-2-diphenylmetoxyethylamine; 8-Chloro theophyllinate) is a salt of two drugs: diphenhydramine and 8-chlorotheophylline, a chlorinated derivative of the theophylline [1]. It is used therapeutically as an antiemetic, antinauseant and to prevent motion sickness [2]. Diphenhydramine overdose causing hyperpyrexia, status epilepticus, coma, and cardiac arrhytmias has been reported [3,4]. Additionally, life-threatening ventricular dysrhythmias were reported in a 4 month-old infant intentionally administered an overdose of dimenhydrinate [5].
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