Abstract
The gammaherpesviruses (γHVs) are lymphotropic herpesviruses, associated with lymphoproliferation and a range of tumors. Given these properties, intense efforts have focused on understanding pro-proliferative γHV gene products. Many γHVs encode a functional cyclin D homolog, referred to as the viral cyclin. Studies on the γHV viral cyclins (vCyclins) have provided new insights into viral subversion of cell cycle machinery, with vCyclins characterized by expanded activity and reduced susceptibility to host inhibitory mechanisms. Studies from both human and mouse γHVs have shown that the vCyclins have critical roles in promoting chronic γHV infection, including promoting reactivation from latency and promoting tumorigenesis in various immunodeficient hosts. This review emphasizes major themes uncovered through the study of the vCyclins across the γHVs.
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