Multifaceted Biomedical Applications of Functional Graphene Nanomaterials to Coated Substrates, Patterned Arrays and Hybrid Scaffolds.

Yong Shin,Jae-Chang Lee,Seung Jeong,Dong-Wook Han,Su-Jin Song,Suck Hong,Wojciech Chrzanowski

doi:10.3390/nano7110369

Abstract

Because of recent research advances in nanoscience and nanotechnology, there has been a growing interest in functional nanomaterials for biomedical applications, such as tissue engineering scaffolds, biosensors, bioimaging agents and drug delivery carriers. Among a great number of promising candidates, graphene and its derivatives—including graphene oxide and reduced graphene oxide—have particularly attracted plenty of attention from researchers as novel nanobiomaterials. Graphene and its derivatives, two-dimensional nanomaterials, have been found to have outstanding biocompatibility and biofunctionality as well as exceptional mechanical strength, electrical conductivity and thermal stability. Therefore, tremendous studies have been devoted to employ functional graphene nanomaterials in biomedical applications. Herein, we focus on the biological potentials of functional graphene nanomaterials and summarize some of major literature concerning the multifaceted biomedical applications of functional graphene nanomaterials to coated substrates, patterned arrays and hybrid scaffolds that have been reported in recent years.

Highlights

Over the last several decades, the development of nanoscience and nanotechnology has made dramatic progress in research towards the understanding of nanomaterials
Tremendous studies have been underway to employ graphene and graphene derivatives for biomedical applications by introducing functional groups on their surface, or by using them as surface coating, nanofiller and composite materials. Among these various types of applications, the aim of the present review is to summarize the recent studies concerning multifaceted biomedical applications of functional graphene nanomaterials to coated substrates, patterned arrays and hybrid scaffolds
Splendid progress in nanoscience and nanotechnology has invigorated interest in application of nanomaterials to biomedical fields

Summary

Introduction

Over the last several decades, the development of nanoscience and nanotechnology has made dramatic progress in research towards the understanding of nanomaterials. The interactions of graphene and graphene derivatives with biological systems are quite varied depending on many parameters, including their size, shape, concentration, surface functional group, exposure time and preparation method; thereby, research on the biomedical applications of graphene nanomaterials is still in its infancy. Tremendous studies have been underway to employ graphene and graphene derivatives for biomedical applications by introducing functional groups on their surface, or by using them as surface coating, nanofiller and composite materials. Among these various types of applications, the aim of the present review is to summarize the recent studies concerning multifaceted biomedical applications of functional graphene nanomaterials to coated substrates, patterned arrays and hybrid scaffolds

Graphene Nanomaterial-Coated Substrates

Methods & Findings

Graphene Nanomaterial-Patterned Arrays

Graphene Nanomaterial-Based Hybrid Scaffolds

Conclusions