Abstract
To the Editor: Acinetobacter baumannii is an opportunistic pathogen that is a source of nosocomial infections, mostly pneumonia (1). Treatment of infections caused by A. baumannii is becoming a serious clinical concern as this microorganism becomes increasingly resistant to multiple antimicrobial drugs (2). A. baumannii resistance to carbapenems is mostly associated with production of carbapenem-hydrolyzing class D β-lactamases and metallo-β-lactamases (2). New Delhi metallo-β-lactamase 1 (NDM-1) is one of the most recently discovered metallo-β-lactamases among various gram-negative species, including A. baumannii (3). We recently reported the recovery of NDM-1–producing A. baumannii isolates throughout Europe (4). In that study, the genetic background of several strains was identified and corresponded to sequence types (STs) 1, 25 and 85. The ST85 clone was isolated in France from 2 patients previously hospitalized in Algeria (4,5).
Highlights
To the Editor: Acinetobacter baumannii is an opportunistic pathogen that is a source of nosocomial infections, mostly pneumonia [1]
The isolates were resistant to fluoroquinolones, gentamicin, sulfonamides, and chloramphenicol but susceptible to amikacin, netilmicin, rifampin, tetracycline, and tigecycline according to Clinical and Laboratory Standards Institute guidelines [6] and colistin according to European Committee on Antimicrobial Susceptibility Testing guidelines
Genotypic comparison was performed by multilocus sequence typing as described [8] and by repetitive extragenic palindromic sequence-based PCR by using the DiversiLab system according to the manufacturer’s instructions
Summary
To the Editor: Acinetobacter baumannii is an opportunistic pathogen that is a source of nosocomial infections, mostly pneumonia [1]. The isolates were identified by 16S rRNA gene sequencing. Susceptibility testing was performed by disk diffusion (Sanofi-Diagnostic Pasteur, Marnes La Coquette, France) and interpreted according to updated Clinical and Laboratory Standards Institute guidelines [6]. All isolates were resistant to β-lactams, including all carbapenems (MICs >32mg/L).
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