Multidrug-resistant organisms (MDRO) patterns of GICU patients in Dr Mohammad Hoesin Hospital Palembang

Abstract

Multidrug-Resistant Organisms (MDRO) are organisms (bacteria) that are resistant to at least one antimicrobial of ≥3 antimicrobial classes. MDRO transmission most recorded in General intensive care unit (|GICU), which is also the high risk units of nosocomial infection. A total of 549 from 611 samples (89.8%) was identified as MDRO in 2015 and as many as 490 of the 552 samples (88.7%) in 2016. The most gram-negative bacteria in 2015 and 2016 were Acinetobacter baumannii (33% vs 30.4%), followed by Pseudomonas aeruginosa (24% vs 29.3%) and Klebsiella pneumoniae (11% vs 13.2%). In 2015, gram-positive bacteria had the highest level of resistance to antibiotics norfloxacin and ceftazidime, while in 2016 gram-positive bacteria had the high levels of resistance to antibiotics cotrimoxazole and ceftazidime. Gram-negative bacteria in 2015 had resistance to the antibiotic ampicillin, cefazolin, and tigecycline, whereas, in 2016, Gram-negative bacteria had resistance to the antibiotic imipenem, cefazolin, and tigecycline. The incidence of MDRO in 2016 decreased compared to 2015. In 2015 and 2016, a bacterial infection of GICU patient more often caused by gram-negative bacteria.