Abstract
Multidrug-resistant (MDR) cancer may be treated using combinations of encapsulated cytotoxic drugs or chemo sensitizers. To optimize for the effectiveness of this combinational approach poly (lactic-o-glycolic acid) nanoparticle formulations capable of delivering a cytotoxic drug or chemo sensitizers, ursolic acid (UA) and Caffeine (Caf) combination were prepared. The system can be used for targeting, controlled drug delivery and also imaging of cancer cells. The prepared nanoparticles were characterized using DLS, TEM, XRD and FT-IR a studies. The drug loaded nanoparticles exhibited significant antitumor effects and high tumour targeting ability towards HT29 human colon cancer cells. The aforementioned results indicated that the drug loaded nanoparticle prepared in the study had a specific interaction with colon cells. Therefore, the prepared nanoparticle may be used as a potential drug delivery system for the targeted delivery to colon cancers.
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