Abstract
Development of new way and system for multidrug delivery has recently attracted much attention and became one of major issue in drug delivery research. Although this research field is still immature compared to the single drug delivery system, intensive efforts have recently been devoted by researchers in order to realize more efficient, functional, and safe combination therapy using multiple drugs or agents. In this review article, we outline several targets in terms of application for biochemical modulation together with various concrete attempts of simultaneous and sequential delivery of multiple drugs or agents with single formulation. Finally, we will also summarize the possible contribution of biomaterial sciences and nanobiotechnology for improvement of future multidrug delivery system.
Highlights
Almost all diseases, especially intractable diseases such as cancer and human immunodeficiency virus infection, cannot cure by treatment with only one type of drug because of pathological complexity
This research field is still immature compared to the single drug delivery system, intensive efforts have recently been devoted by researchers in order to realize more efficient, functional, and safe combination therapy using multiple drugs or agents
The development of multi drug delivery systems (M DDSs) with single formulation that matched for Biochemical modulation (BCM) regimens has been expected
Summary
Especially intractable diseases such as cancer and human immunodeficiency virus infection, cannot cure by treatment with only one type of drug because of pathological complexity. The development of multi drug delivery systems (M DDSs) with single formulation that matched for BCM regimens has been expected. Some DDS formulations have already been reached to the market [12,13,14,15], and the established DDSs, especially for cancer chemotherapy, have successfully improved therapeutic outcome of conventional drugs and the patient’s quality of life. Many researchers have made huge effort to develop MDDS, and various MDDSs, which can adopt for combination therapy, have been established These attempts have been well summarized in some previous review articles that are described based on the types of formulation [16,17,18].
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