Abstract
We studied multidrug transport in human autoimmune T line cells and peripheral blood leukocytes, because muitidrug transport is pleiotropically limiting the intracellular accumulation of immunosuppressive and chsmotherapeutie agents. We observed that a subpopulation of peripheral blood leukocytes containing CD4+. CD8+ and Ig+ lymphocytes expressed a muitidrug transport system. Lymphocytic muitidrug transport was seen with all peripheral blood samples analyzed, but showed considerable variations between individuals. In further studies with human lymphocytic cell lines multidrug transport was seen with 1823 human CD4+ T cell lines, interestingly, expression of multidrug transport was independent of T cell activation. No significant transport was observed with EBV-transformed human B lymphocytes, rat T line cells or rat, mouse, or guinea pig leukocytes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
