Abstract
Temporal summation of heat pain during repetitive stimulation is dependent on C nociceptor activation of central N‐methyl‐D‐aspartate (NMDA) receptor mechanisms. Moderate temporal summation is produced by sequential triangular ramps of stimulation that control skin temperature between heat pulses but do not elicit distinct first and second pain sensations. Dramatic summation of second pain is produced by repeated contact of the skin with a preheated thermode, but skin temperature between taps is not controlled by this procedure. Therefore, relationships between recordings of skin temperature and psychophysical ratings of heat pain were evaluated during a series of repeated skin contacts. The conclusion was that the magnitude of aching pain was well related to skin temperature and thus appeared to be established primarily by peripheral factors.
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