Multidisciplinary management of patients with BRCA1 and BRCA2 mutations in institut Curie of paris

Abstract

1.1. Three strains of influenza virus have been purified by adsorption on to and elution from aluminium phosphate, followed by differential centrifugation.2.2. The total virus was submitted to the Schmidt-Thannhauser hydrolytic procedure and the resulting ribonucleotide mixture was analysed by ion-exchange chromatography. Paper ionophoresis was not satisfactory in the presence of protein.3.3. The ribonucleic acid content of the two spherical A strains (WS and MEL) was just over 1%, and there was a very much smaller proportion of deoxyribonucleic acid. The partly filamentous Persian strain contained only about 0.4% of ribonucleic acid.4.4. The results as regards spherical strains differed slightly but significantly from those of Ada and Perry2. In the present work the ratio of 6-amino/6-oxo bases was approximately 1, and the purine/pyrimidine ratio was unusually low.