Multidisciplinary in treatment of brain glioblastoma: The combination of surgery, radiotherapy and chemotherapy

Abstract

ABSTRACT Objectives: To describe the clinical features and magnetic resonance imaging of cerebral glioblastoma. And to evaluate the results of surgery combined with radiotherapy and chemotherapy for the group of patients. Methods: A case series study was conducted on 38 patients with brain glioblastoma who underwent microsurgery combined with radiochemotherapy and Temozolomide at a dose of 75mg/m2 daily and maintenance chemotherapy with Temozolomide at a dose of 175mg/m2 for 6 cycles at Hue Central Hospital during 9/2019 - 6/2023. Results: The mean age was 54.5 ± 10.3 with the male/female ratio = 1.57. The location was mainly in frontal lobe (26.3%). The tumor size 3 - 5 cm accounted for 50% of the patients. Magnetic resonance imaging showed mixed structures (47.4%) and heterogeneous enhancement (94.7%). Most patients underwent partial resection (65.8%). The main radiation dose was 59.4gy - 60gy, the patients with IMRT radiotherapy technique accounting for 23.7% After treatment treatment, the percentage of patients with symptoms such as headache and nausea reduced by about 30%. Partial response accounted for 50% of cases. The mean progression-free survival was 10.2 ± 1.06 months. The mean overall survival was 19,9 ± 1,84 months. Conclusion: Glioblastoma was a highly malignant and rapidly progressive. Combination of radiotherapy and chemotherapy after surgery improved symptoms and increased overal survival.