Abstract
Introduction: Moebius syndrome presents the following alterations: facial paralysis, ocular abduction, superior ankyloglossia and loss of integrity of the palatal platform among other alterations. 
 Objective: To systematically review the multidisciplinary behavioral management of Moebius Syndrome anomalies from 2019 to 2023 for the purpose of integrating a guiding protocol.
 Methodology: A systematic review was carried out considering the prism method. The following databases were used: Web of Science, Scopus and Scielo.
 Results: A total of 25 articles were selected according to the systematization process where it is evident that 40% deal with facial paralysis and the most frequent area is Surgery.
 Conclusion: Early diagnosis is essential for adequate management of the syndrome. It is necessary to address the facial paralysis, as well as the other alterations. It is recommended to provide emotional support to the patient and caregivers.
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