Abstract
Working memory has a capacity of several items. In a simple experimental paradigm of spatial working memory, such as oculomotor delayed-response tasks, this means that more than one target with different locations can be stored at once. This study explores whether the proposed prefrontal cortical circuit model can have such capability. The simulation shows successful or unsuccessful loading of multiple targets, either simultaneously or sequentially, depending on the values of the circuit parameters. This study suggests that the NMDA receptors and the cross-directional inhibition play critical roles in controlling the multi-target representation of spatial working memory.
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