Abstract
We present the case of 80-year-old male with superficial papillary urothelial carcinoma of the urinary bladder with striking multicystic architecture with a combination of features of urothelial carcinoma with gland-like lumina, with signet-ring cell differentiation and microcystic pattern. However, the tumor shared the morphologic features of several variants of urothelial carcinoma, the most important differential diagnosis covered so-called florid Brunneriosis, cystitis cystica, and primary adenocarcinomas of the urinary bladder.
Highlights
Urothelial carcinomas, high-grade tumors, may show divergent differentiation
The latter represents microcystic change within otherwise typical urothelial carcinoma. These spaces may contain mucin, they differ from urothelial carcinoma admixed with a well-defined adenocarcinoma component [1]
We present a case of low-grade papillary urothelial carcinoma characterized by striking degrees of glandular differentiation, microcystic change and signet ring cell morphology
Summary
Urothelial carcinomas, high-grade tumors, may show divergent differentiation. Urothelial carcinomas with true glandular differentiation must be distinguished from urothelial carcinomas with gland-like lumina. The latter represents microcystic change within otherwise typical urothelial carcinoma. We present a case of low-grade papillary urothelial carcinoma characterized by striking degrees of glandular differentiation, microcystic change and signet ring cell morphology.
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