Abstract

This study evaluates the effects of Multicondition Training (MCT) on computer aided diagnosis systems for voice quality assessment associated to exudative lesions of Reinke’s space. This technique adds various noise conditions to the speech recordings in order to recreate realistic acoustic environments. Four different databases (Massachussets Eye and Ear Infirmary, UEX-Voice, Saarbrucken, and Hospital Universitario Principe de Asturias) recorded in very different acoustic environments are used. We compare the outcomes of random forest classifier models comprising feature selection, hyperparameter tuning, and cross-validation attending the specific MCT schema used to separate healthy from pathological subjects for three diseases (nodules, polyps, and Reinke’s edema). Apart from the clean case baseline, an asymmetric (one subject recording is affected only by one noise recording) and two symmetric (one subject recording is affected by all the noise recordings) noise-based MCT scenarios are considered. These scenarios are created by adding realistic acoustic noise of different types to the sustained /a/ vowel recordings. The symmetric approaches are affected by methodological concerns and are tested with a comparative purpose, to emphasize these issues. Experimental results highlight the drawbacks of symmetric MCTs and exclude these techniques as a viable option. In contrast, asymmetric MCT is proven to be a suitable noise-robust approach to build a diagnosis system for exudative lesions of Reinke’s space, as performance obtained with the resulting classifiers is not far from the performance obtained for clean training.

Highlights

  • Human voice production can be affected by a wide range of conditions, either vocal specific like nodules, polyps, cleft lip and palate, or by other disorders which affect motor control like neurodegenerative diseases

  • It is for such that Computer Aided Diagnosis (CAD) tools are of great interest since they can help diagnosis procedures by using voice recordings as a noninvasive biomarker

  • All vocal recordings were processed in the same way: First, all samples were trimmed down to 1 second length in order to ensure homogeneous length across databases; later, all of them were downsampled to 16 kHz prior corruption in order to match noise files sampling rate; after that, noise was added from all sources at all proposed Signalto-Noise Ratio (SNR); preprocessing was applied to the sound files prior feature extraction, normalizing amplitude to range [−1, 1]; and lastly, feature extraction was performed for each recording

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Summary

Introduction

Human voice production can be affected by a wide range of conditions, either vocal specific like nodules, polyps, cleft lip and palate, or by other disorders which affect motor control like neurodegenerative diseases. Polyps, and Reinke’s edema are the main lesions that occur in Reinke’s space [1] Their etiologic factors are different, their pathologic features are quite similar and diagnosis usually relies on the clinical description of. Classical voice quality assessment relies on cumbersome techniques such as videostroboscopy or laryngoscopy, procedures which are highly invasive and uncomfortable for patients, and require expensive equipment and expert practitioners. It is for such that Computer Aided Diagnosis (CAD) tools are of great interest since they can help diagnosis procedures by using voice recordings as a noninvasive biomarker. They are non-intrusive as they only perform signal processing of voice samples [2]

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