Multicomponent synthesis of functionalized 2-amino-4<i>H</i>-pyrans initiated by the Knoevenagel reaction

Abstract

The multicomponent condensation of aldehydes, malononitrile derivatives, 1,3-dicarbonyl compounds of the carbo- and heterocyclic series, and alkyl halides has been studied. The transformation is initiated by the Knoevenagel reaction and leads to the formation of functionally substituted condensed 2-amino- 4 H-pyrans. The structure of a number of products was studied by X-ray diffraction.