Abstract
The present study reports nine crystalline forms of diclofenac acid which include cocrystals, salts, salt-cocrystals and salt hydrates with pyridines and amines based coformers utilizing acid … pyridine synthon. All the solids were successfully prepared and structurally characterized through PXRD, ATR, DSC and single crystal XRD. The crystal structures were analyzed and discussed in terms of acid … pyridine heterosynthon. The conformation of diclofenac acid in the multicomponent solids reported in this paper is compared with its polymorphs. The structural chemistry of diclofenac acid (DIC) is discussed based on carboxylic acid … pyridine synthon in terms of DIC-coformer dimer or DIC-coformer-DIC trimers. The influence of pKa in dictating the final solid is also discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
